This multicentre RCT explores new opioid-free techniques using large doses of opioid-sparing analgesic medications instead of opioids, for elective laparoscopic cholecystectomy or laparoscopic tubal ligation surgery. We will compare two groups, one that receives a particular standardised opioid free technique with another group that receives standardised opioid-based anaesthesia. We will compare patient-centred outcomes between the groups, including QoR-15, pain scores and opioid-induced side effects. This prospective, randomized, parallel group, single-blind study, with concealed allocation of 80 participants aged 18-65 years old with body mass index of 35 kg/m2 or less, scheduled for elective laparoscopic cholecystectomy or laparoscopic tubal ligation surgery, with ASA Score of I-II.
Opioid free anaesthesia may reduce sedation, nausea, itch, and constipation. Cost benefits may result from fewer unplanned Intensive Care and High Dependency Unit admissions for respiratory depression or sedation.
The Australian and New Zealand College of Anaesthetists recognizes the rising prescription and risk of opioids and supports Opioid Stewardship Programs. Our project aligns with this aim, of maximising the effect of opioid sparing agents to reduce overall opioid use and reduced healthcare costs to the community.
Our results may support the widespread adoption of OFA, with the benefits of reduced side-effects.
Dr Anthony Eidan, Royal Brisbane and Women’s Hospital, Queensland.
The project was awarded A$19,134 funding through the ANZCA research grants program for 2024.